Calcium so you’re able to Phosphorus Proportion, PTH, and you may Limbs Wellness
Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ
Estimates by the Ray Peat, PhD: “The fresh new proportion out-of calcium to help you phosphate is important; for this reason whole milk and you may mozzarella cheese are worthwhile for weight loss, or even for blocking gaining weight. For individuals who aren’t very effective, low fat milk products and parmesan cheese function better, as the body fat fat commonly expected.”
“The meals large for the phosphate, in accordance with calcium, was grain, legumes, beef, and seafood. Of many waiting meals consist of added phosphate. Items having a top, safer proportion out-of calcium so you can phosphate try renders, such as for example kale, turnip greens, and you will beet vegetables, and lots of fresh fruit, whole milk, and you can cheddar.”
Br J Nutr
“Free unsaturated efas activate pressure hormone, and you will cortisol prevents oxidation away from sugar and you will converts they on oily acids and you can triglycerides. Keeping cortisol and worry reasonable is the main issue. Remaining a leading ratio from calcium supplements in order to phosphate helps to contradict pressure k-calorie burning.” “Previous guide are exhibiting one to a lot of phosphate can increase soreness, structure atrophy, calcification out-of bloodstream, cancer, alzhiemer’s disease, www.datingranking.net/escort-directory/scottsdale and you will, generally, the brand new procedure out-of ageing.”
2006 Sep;96(3):545-52. Higher phosphorus intakes incredibly and you will negatively connect with California and you will bones metabolic process inside the a dosage-created fashion inside the fit more youthful ladies. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. California and you may P was one another important nourishment to own bone and tend to be known to apply at perhaps one of the most essential government from limbs kcalorie burning, parathyroid hormonal (PTH). Too generous an excellent P intake, typical from West diet, is deleterious in order to bone from the enhanced PTH secretion. Pair controlled dose-effect studies are on the consequences of high P consumption from inside the son. I analyzed the brand new small-title outcomes of five P dosages for the California and you will limbs metabolic process during the fourteen compliment ladies, 20-twenty-eight years old, have been randomized to four controlled study weeks; thus for each investigation subject supported just like the her very own control. P enhance amounts off 0 (placebo), 250, 750 or 1500 milligrams was in fact pulled, split into about three amounts within the data go out. The meals served was equivalent during for every investigation go out and you will given 495 milligrams P and 250 milligrams Ca. The fresh P dosage affected the new serum PTH (S-PTH) inside the an amount-centered styles (P=0.0005). Discover a reduction in solution ionized Ca concentration just inside the highest P amount (P=0.004). The fresh new marker of limbs formation, bone-certain alkaline phosphatase, reduced (P=0.05) therefore the bone resorption marker, N-critical telopeptide out of collagen kind of I, improved as a result with the P dosages (P=0.05). It managed dosage-reaction study revealed that P has a dose-situated influence on S-PTH and you may grows PTH hormonal somewhat when California consumption try lower. Exceedingly high P intake adversely affects bone kcalorie burning by decreasing bones development and you will increasing bones resorption, once the shown from the limbs metabolism indicators.
20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.